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Home  ›  How Long Can A Rabid Animal Live

How Long Can A Rabid Animal Live

Written By Friday, June 24, 2022 Add Comment Edit

Deadly viral illness, transmitted through animals

Medical status

Rabies
Manwithrabies4.png
A man with rabies, 1958
Specialty Infectious disease
Symptoms Fever, fear of water, confusion, excessive salivary secretion, hallucinations, disrupted sleep, paralysis, coma[1] [two] Hyperactivity, Headache, Nausea, Airsickness, Anxiety, Airsickness.[3]
Causes Rabies virus, Australian bat lyssavirus[4]
Prevention Rabies vaccine, animal command, rabies immunoglobulin[1]
Treatment Supportive care
Prognosis Nearly 100% fatal later on onset of symptoms[1]
Deaths 59,000 per year worldwide[v]

Rabies is a viral affliction that causes inflammation of the brain in humans and other mammals.[1] Early symptoms can include fever and tingling at the site of exposure.[1] These symptoms are followed by one or more of the following symptoms: nausea, airsickness, violent movements, uncontrolled excitement, fright of water, an inability to move parts of the body, confusion, and loss of consciousness.[1] [6] [7] [8] Once symptoms appear, the result is about always death, regardless of treatment.[1] The time period between contracting the disease and the start of symptoms is usually ane to three months but can vary from less than one week to more than one year.[1] The time depends on the altitude the virus must travel along peripheral fretfulness to accomplish the primal nervous system.[nine]

Rabies is acquired past lyssaviruses, including the rabies virus and Australian bat lyssavirus.[4] It is spread when an infected animal bites or scratches a human or other animals.[1] Saliva from an infected animate being can also transmit rabies if the saliva comes into contact with the optics, mouth, or olfactory organ.[1] Globally, dogs are the nigh mutual beast involved.[1] In countries where dogs commonly take the disease, more than than 99% of rabies cases are the straight outcome of dog bites.[x] In the Americas, bat bites are the almost mutual source of rabies infections in humans, and less than five% of cases are from dogs.[one] [10] Rodents are very rarely infected with rabies.[10] The disease can be diagnosed but later the start of symptoms.[i]

Creature control and vaccination programs have decreased the risk of rabies from dogs in a number of regions of the earth.[1] Immunizing people earlier they are exposed is recommended for those at high run a risk, including those who piece of work with bats or who spend prolonged periods in areas of the globe where rabies is common.[1] In people who have been exposed to rabies, the rabies vaccine and sometimes rabies immunoglobulin are effective in preventing the disease if the person receives the treatment before the start of rabies symptoms.[1] Washing bites and scratches for 15 minutes with lather and water, povidone-iodine, or detergent may reduce the number of viral particles and may be somewhat effective at preventing transmission.[i] [11] As of 2016[update], only fourteen people had survived a rabies infection after showing symptoms.[12] [13]

Rabies causes almost 59,000 deaths worldwide per year,[5] about forty% of which are in children under the historic period of 15.[14] More than 95% of human deaths from rabies occur in Africa and Asia.[one]

Rabies is present in more than 150 countries and on all continents simply Antarctica.[ane] More than 3 billion people live in regions of the world where rabies occurs.[ane] A number of countries, including Commonwealth of australia and Japan, also as much of Western Europe, practise not have rabies amongst dogs.[15] [16] Many Pacific islands do not take rabies at all.[16] It is classified equally a neglected tropical affliction.[17]

Etymology

The name rabies is derived from the Latin rabies, "madness".[18] This, in plough, may be related to the Sanskrit rabhas, "to rage".[19] The Greeks derived the discussion lyssa, from lud or "fierce"; this root is used in the genus name of the rabies virus, Lyssavirus.[xx]

Signs and symptoms

Man with rabies displaying hydrophobia

Animals with "impaired" rabies announced depressed, lethargic, and uncoordinated

The menses betwixt infection and the first symptoms (incubation period) is typically ane–3 months in humans.[21] This period may be as curt every bit four days or longer than six years, depending on the location and severity of the wound and the amount of virus introduced.[21] Initial symptoms of rabies are often nonspecific such equally fever and headache.[21] As rabies progresses and causes inflammation of the brain and meninges, symptoms can include slight or fractional paralysis, anxiety, insomnia, confusion, agitation, abnormal beliefs, paranoia, terror, and hallucinations.[9] [21] The person may also take fright of h2o.[1]

The symptoms eventually progress to delirium, and coma.[9] [21] Death usually occurs ii to 10 days later on first symptoms. Survival is almost unknown once symptoms have presented, even with intensive intendance.[21] [22]

Rabies has as well occasionally been referred to equally hydrophobia ("fear of h2o") throughout its history.[23] It refers to a set of symptoms in the later on stages of an infection in which the person has difficulty swallowing, shows panic when presented with liquids to drink, and cannot quench their thirst. Any mammal infected with the virus may demonstrate hydrophobia.[24] [ failed verification ] Saliva production is greatly increased, and attempts to potable, or fifty-fifty the intention or suggestion of drinking, may crusade excruciatingly painful spasms of the muscles in the throat and larynx. Since the infected private cannot swallow saliva and water, the virus has a much college chance of existence transmitted, because it multiplies and accumulates in the salivary glands and is transmitted through biting.[25] Hydrophobia is commonly associated with furious rabies, which affects 80% of rabies-infected people. The remaining twenty% may feel a paralytic form of rabies that is marked by muscle weakness, loss of awareness, and paralysis; this form of rabies does not usually cause fear of water.[24]

Crusade

Rendering of the rabies virus

An electron microscope image of rabies virus.

postage stamp with man's head looking to the right

Rabies is acquired past a number of lyssaviruses including the rabies virus and Australian bat lyssavirus.[4] Duvenhage lyssavirus may cause a rabies-like infection.[26]

The rabies virus is the type species of the Lyssavirus genus, in the family unit Rhabdoviridae, gild Mononegavirales. Lyssavirions have helical symmetry, with a length of about 180 nm and a cantankerous-section of nigh 75 nm.[27] These virions are enveloped and have a single-stranded RNA genome with negative sense. The genetic information is packed as a ribonucleoprotein complex in which RNA is tightly bound by the viral nucleoprotein. The RNA genome of the virus encodes five genes whose order is highly conserved: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and the viral RNA polymerase (L).[28]

To enter cells, trimeric spikes on the outside of the membrane of the virus collaborate with a specific cell receptor, the well-nigh likely one being the acetylcholine receptor. The cellular membrane pinches in a procession known as pinocytosis and allows entry of the virus into the cell by way of an endosome. The virus then uses the acidic environment, which is necessary, of that endosome and binds to its membrane simultaneously, releasing its v proteins and single-strand RNA into the cytoplasm.[29]

Once inside a muscle or nerve prison cell, the virus undergoes replication. The L protein then transcribes five mRNA strands and a positive strand of RNA all from the original negative strand RNA using gratis nucleotides in the cytoplasm. These five mRNA strands are then translated into their corresponding proteins (P, Fifty, Northward, Chiliad and Grand proteins) at free ribosomes in the cytoplasm. Some proteins require postal service-translative modifications. For case, the G protein travels through the crude endoplasmic reticulum, where information technology undergoes further folding, and is so transported to the Golgi apparatus, where a sugar grouping is added to it (glycosylation).[29]

When there are enough viral proteins, the viral polymerase will brainstorm to synthesize new negative strands of RNA from the template of the positive-strand RNA. These negative strands will and so grade complexes with the N, P, L and G proteins then travel to the inner membrane of the cell, where a Thou poly peptide has embedded itself in the membrane. The Thou poly peptide and so coils around the N-P-50-M complex of proteins taking some of the host cell membrane with it, which volition form the new outer envelope of the virus particle. The virus then buds from the prison cell.[29]

From the point of entry, the virus is neurotropic, traveling along the neural pathways into the central nervous system. The virus unremarkably outset infects musculus cells close to the site of infection, where they are able to replicate without existence 'noticed' past the host's allowed organization. Once plenty virus has been replicated, they begin to demark to acetylcholine receptors at the neuromuscular junction.[30] The virus then travels through the nervus cell axon via retrograde transport, as its P protein interacts with dynein, a protein present in the cytoplasm of nervus cells. Once the virus reaches the cell body it travels rapidly to the central nervous system (CNS), replicating in motor neurons and eventually reaching the encephalon.[9] Afterwards the brain is infected, the virus travels centrifugally to the peripheral and autonomic nervous systems, eventually migrating to the salivary glands, where information technology is ready to exist transmitted to the adjacent host.[31] : 317

2 dogs with the paralytic, or dumb, grade of rabies

Transmission

All warm-blooded species, including humans, may become infected with the rabies virus and develop symptoms. Birds were starting time artificially infected with rabies in 1884; nonetheless, infected birds are largely, if not wholly, asymptomatic, and recover.[32] Other bird species have been known to develop rabies antibodies, a sign of infection, after feeding on rabies-infected mammals.[33] [34]

The virus has also adapted to grow in cells of cold-blooded vertebrates.[35] [36] Most animals tin can be infected past the virus and tin transmit the disease to humans. Worldwide, near 99% of human being rabies cases come from domestic dogs.[37] Other sources of rabies in humans include bats,[38] [39] monkeys, raccoons, foxes, skunks, cattle, wolves, coyotes, cats, and mongooses (ordinarily either the small Asian mongoose or the yellow mongoose).[40]

Rabies may likewise spread through exposure to infected bears, domestic farm animals, groundhogs, weasels, and other wild carnivorans. However, lagomorphs, such as hares and rabbits, and small-scale rodents, such as chipmunks, gerbils, guinea pigs, hamsters, mice, rats, and squirrels, are almost never constitute to be infected with rabies and are not known to transmit rabies to humans.[41] Bites from mice, rats, or squirrels rarely require rabies prevention because these rodents are typically killed by any encounter with a larger, rabid brute, and would, therefore, not be carriers.[42] The Virginia opossum (a marsupial, unlike the other mammals named in this paragraph, which are all eutherians/placental), has a lower internal torso temperature than the rabies virus prefers and therefore is resistant only not immune to rabies.[43] Marsupials, along with monotremes (platypuses and echidnas), typically have lower trunk temperatures than similarly sized eutherians.[44]

The virus is normally present in the fretfulness and saliva of a symptomatic rabid animal.[45] [46] The route of infection is usually, only not always, by a bite. In many cases, the infected brute is exceptionally aggressive, may assault without provocation, and exhibits otherwise uncharacteristic behavior.[47] This is an example of a viral pathogen modifying the behavior of its host to facilitate its manual to other hosts. Later on a typical human infection by bite, the virus enters the peripheral nervous system. Information technology then travels retrograde forth the efferent nerves toward the central nervous arrangement.[48] During this stage, the virus cannot exist easily detected within the host, and vaccination may still confer jail cell-mediated immunity to prevent symptomatic rabies. When the virus reaches the brain, it rapidly causes encephalitis, the prodromal phase, which is the beginning of the symptoms. Once the patient becomes symptomatic, handling is nigh never constructive and bloodshed is over 99%. Rabies may too inflame the spinal cord, producing transverse myelitis.[49] [50]

Although it is theoretically possible for rabies-infected humans to transmit it to others by biting or otherwise, no such cases have ever been documented, because infected humans are usually hospitalized and necessary precautions taken. Casual contact, such as touching a person with rabies or contact with non-infectious fluid or tissue (urine, claret, feces), does not constitute an exposure and does not crave postal service-exposure prophylaxis. But as the virus is present in sperm and vaginal secretions, it might be possible for rabies to spread through sex.[51] At that place are just a handful of recorded cases of homo-to-human transmission of rabies, and all occurred through organ transplants from infected donors.[52] [53]

Diagnosis

Rabies can exist difficult to diagnose because, in the early stages, it is easily confused with other diseases or even with a simple aggressive temperament.[54] The reference method for diagnosing rabies is the fluorescent antibody test (FAT), an immunohistochemistry procedure, which is recommended by the World Health Arrangement (WHO).[55] The Fat relies on the ability of a detector molecule (usually fluorescein isothiocyanate) coupled with a rabies-specific antibiotic, forming a conjugate, to demark to and allow the visualisation of rabies antigen using fluorescent microscopy techniques. Microscopic analysis of samples is the but straight method that allows for the identification of rabies virus-specific antigen in a short time and at a reduced toll, irrespective of geographical origin and status of the host. It has to exist regarded as the outset stride in diagnostic procedures for all laboratories. Autolysed samples can, even so, reduce the sensitivity and specificity of the Fat.[56] The RT PCR assays proved to be a sensitive and specific tool for routine diagnostic purposes,[57] particularly in decomposed samples[58] or archival specimens.[59] The diagnosis can exist reliably made from brain samples taken after death. The diagnosis can also exist made from saliva, urine, and cerebrospinal fluid samples, but this is not equally sensitive or reliable equally brain samples.[56] Cerebral inclusion bodies called Negri bodies are 100% diagnostic for rabies infection merely are establish in only about 80% of cases.[27] If possible, the fauna from which the bite was received should as well be examined for rabies.[60]

Some lite microscopy techniques may besides exist used to diagnose rabies at a tenth of the price of traditional fluorescence microscopy techniques, allowing identification of the affliction in less-developed countries.[61] A test for rabies, known every bit LN34, is easier to run on a dead creature's brain and might assistance determine who does and does not need mail service-exposure prevention.[62] The examination was developed past the CDC in 2018.[62]

The differential diagnosis in a case of suspected homo rabies may initially include any cause of encephalitis, in detail infection with viruses such as herpesviruses, enteroviruses, and arboviruses such equally Due west Nile virus. The most important viruses to dominion out are herpes simplex virus type 1, varicella zoster virus, and (less unremarkably) enteroviruses, including coxsackieviruses, echoviruses, polioviruses, and human enteroviruses 68 to 71.[63]

New causes of viral encephalitis are likewise possible, as was evidenced past the 1999 outbreak in Malaysia of 300 cases of encephalitis with a mortality rate of 40% acquired by Nipah virus, a newly recognized paramyxovirus.[64] Likewise, well-known viruses may exist introduced into new locales, as is illustrated by the outbreak of encephalitis due to Due west Nile virus in the eastern U.s.a..[65] Epidemiologic factors, such as season, geographic location, and the patient's age, travel history, and possible exposure to bites, rodents, and ticks, may help direct the diagnosis.[ citation needed ]

Prevention

Well-nigh all human exposure to rabies was fatal until a vaccine was developed in 1885 by Louis Pasteur and Émile Roux. Their original vaccine was harvested from infected rabbits, from which the virus in the nerve tissue was weakened by allowing it to dry for five to ten days.[66] Similar nervus tissue-derived vaccines are still used in some countries, as they are much cheaper than modern cell culture vaccines.[67]

The human diploid cell rabies vaccine was started in 1967. Less expensive purified chicken embryo cell vaccine and purified vero cell rabies vaccine are now bachelor.[60] A recombinant vaccine chosen V-RG has been used in Belgium, France, Germany, and the The states to preclude outbreaks of rabies in undomesticated animals.[68] Immunization earlier exposure has been used in both human and nonhuman populations, where, equally in many jurisdictions, domesticated animals are required to exist vaccinated.[69]

A young daughter about to receive PEP after being bitten by an fauna thought to be rabid

The Missouri Department of Wellness and Senior Services Catching Disease Surveillance 2007 Almanac Study states the post-obit can help reduce the risk of contracting rabies:[70]

  • Vaccinating dogs, cats, and ferrets against rabies
  • Keeping pets under supervision
  • Not treatment wild animals or strays
  • Contacting an brute command officer upon observing a wild creature or a stray, especially if the animal is interim strangely
  • If bitten by an animal, washing the wound with soap and water for 10 to 15 minutes and contacting a healthcare provider to determine if post-exposure prophylaxis is required

28 September is World Rabies Day, which promotes the data, prevention, and emptying of the illness.[71]

In Asia and in parts of the Americas and Africa, dogs remain the principal host. Mandatory vaccination of animals is less effective in rural areas. Especially in developing countries, pets may not be privately kept and their devastation may be unacceptable. Oral vaccines tin can be safely distributed in baits, a do that has successfully reduced rabies in rural areas of Canada, France, and the United States. In Montreal, Quebec, Canada, baits are successfully used on raccoons in the Mountain-Majestic Park area. Vaccination campaigns may be expensive, but cost-benefit analysis suggests baits may be a cost-effective method of control.[72] In Ontario, a dramatic drop in rabies was recorded when an aerial bait-vaccination campaign was launched.[73]

The number of recorded human being deaths from rabies in the United States has dropped from 100 or more annually in the early 20th century to one or two per year due to widespread vaccination of domestic dogs and cats and the evolution of human being vaccines and immunoglobulin treatments. Nigh deaths at present result from bat bites, which may go unnoticed by the victim and hence untreated.[74]

Treatment

After exposure

Handling later on exposure can prevent the disease if given within 10 days. The rabies vaccine is 100% constructive if given early, and however has a chance of success if delivery is delayed.[27] [29] [75] Every year, more than xv million people get vaccinated afterwards potential exposure. While this works well, the cost is significant.[76] In the United states it is recommended people receive i dose of human rabies immunoglobulin (HRIG) and four doses of rabies vaccine over a 14-24-hour interval period.[77] HRIG is expensive and makes upwardly most of the price of mail service-exposure handling, ranging as high as several thousand dollars.[78] In the UK, one dose of HRIG costs the National Wellness Service £1,000,[79] although this is non flagged every bit a "high-cost medication".[eighty] A full course of vaccine costs £120–180.[81] As much every bit possible of HRIG should be injected around the bites, with the balance being given by deep intramuscular injection at a site distant from the vaccination site.[29]

People who have previously been vaccinated against rabies do not need to receive the immunoglobulin—but the postexposure vaccinations on days 0 and 3.[82] The side effects of mod cell-based vaccines are like to the side effects of flu shots. The old nerve-tissue-based vaccination required multiple injections into the abdomen with a big needle but is inexpensive.[60] It is being phased out and replaced past affordable World Health Organisation intradermal-vaccination regimens.[sixty] Intramuscular vaccination should exist given into the deltoid, not the gluteal surface area, which has been associated with vaccination failure[ commendation needed ] due to injection into fatty rather than muscle. In children less than a year old, the lateral thigh is recommended.[83] Thoroughly washing the wound as shortly as possible with lather and water for approximately five minutes is effective in reducing the number of viral particles.[84] Povidone-iodine or alcohol is and then recommended to reduce the virus further.[85]

Awakening to detect a bat in the room, or finding a bat in the room of a previously unattended kid or mentally disabled or intoxicated person, is an indication for post-exposure prophylaxis (PEP). The recommendation for the precautionary use of PEP in bat encounters where no contact is recognized has been questioned in the medical literature, based on a price–do good analysis.[86] Nonetheless, a 2002 written report has supported the protocol of precautionary administration of PEP where a child or mentally compromised private has been alone with a bat, peculiarly in sleep areas, where a bite or exposure may occur with the victim being unaware.[87]

After onset

At to the lowest degree 2 treatment schemes have been proposed for treating rabies afterward the onset of symptoms, the Milwaukee Protocol and the Recife Protocol. The Milwaukee Protocol was first used in 2003 on Jeanna Giese, who became the first person known to have survived rabies without preventive treatments earlier symptom onset. The protocol puts a person into a chemically induced coma and uses antiviral medications to foreclose fatal dysautonomia. The overall protocol is complex; the sixth version of the protocol final updated in 2018 consists of 17 pages with 22 steps of treatment, detailed monitoring, and a timeline of expected complications.[88] The Recife Protocol follows the same principle but differs in details like termination of sedation and supplementary medication.[89]

Prognosis

Vaccination later exposure, PEP, is highly successful in preventing rabies.[75] In unvaccinated humans, rabies is nearly always fatal later neurological symptoms accept developed.[ninety]

Epidemiology

Deaths from rabies per million persons in 2012

 0

 1

 2–4

 5–9

 10–17

 xviii–69

Map of rabies-free countries and territories

In 2010, an estimated 26,000 people died from rabies, down from 54,000 in 1990.[91] The majority of the deaths occurred in Asia and Africa.[90] Every bit of 2015[update], Republic of india, followed past China (approximately 6,000) and the Democratic republic of the congo (5,600), had the most cases.[92] A 2015 collaboration between the Globe Health System, World Organization of Animate being Wellness (OIE), Food and Agriculture Organization of the United Nation (FAO), and Global Alliance for Rabies Command has a goal of eliminating deaths from rabies by 2030.[93]

Republic of india

Republic of india has the highest charge per unit of human rabies in the earth, primarily because of stray dogs,[94] whose number has greatly increased since a 2001 law forbade the killing of dogs.[95] Constructive control and treatment of rabies in India is hindered past a course of mass hysteria known equally puppy pregnancy syndrome (PPS). Dog bite victims with PPS, male equally well as female, become convinced that puppies are growing inside them, and often seek help from organized religion healers rather than medical services.[96] An estimated xx,000 people die every year from rabies in India, more than than a third of the global full.[95]

Australia

Australia has an official rabies-free status,[97] although Australian bat lyssavirus (ABLV), discovered in 1996, is a strain of rabies prevalent in Australian native bat populations. There take been iii human cases of ABLV in Australia, all of them fatal.[ citation needed ]

United States

Rabies cases in humans and domestic animals — Usa, 1938–2018

Canine-specific rabies has been eradicated in the United states of america. Only rabies is common amongst wild animals in the The states, and an boilerplate of 100 dogs become infected from other wild animals each year.[98] [99] Bats, raccoons, skunks, and foxes account for well-nigh all reported cases (98% in 2009). Rabid bats are found in all 48 face-to-face states. Other reservoirs are more than limited geographically; for example, the raccoon rabies virus variant is merely found in a relatively narrow band along the E Coast.[ citation needed ]

Due to high public awareness of the virus, efforts at vaccination of domestic animals and curtailment of feral populations, and availability of postexposure prophylaxis, incidence of rabies in humans is very rare in the The states. From 1960 to 2018, a total of 125 human rabies cases were reported in the United States; 36 (28%) were attributed to dog bites during international travel.[100] Amongst the 89 infections acquired in the United States, 62 (lxx%) were attributed to bats.[100] The most contempo rabies death in the U.s.a. was an Illinois human who refused handling after waking up in the night with a bat on his neck; the man died a calendar month later.[101] Occurring in 2021, it was the first case of man rabies in the United States in nigh three years.

Europe

Either no or very few cases of rabies are reported each year in Europe; cases are contracted both during travel and in Europe.[102]

In Switzerland the disease was about eliminated subsequently scientists placed craven heads laced with live attenuated vaccine in the Swiss Alps.[73] The foxes of Switzerland, proven to be the main source of rabies in the country, ate the chicken heads and immunized themselves.[73] [103]

Italy, after beingness alleged rabies-complimentary from 1997 to 2008, has witnessed a reemergence of the disease in wild animals in the Triveneto regions (Trentino-Alto Adige/Südtirol, Veneto and Friuli-Venezia Giulia), due to the spreading of an epidemic in the Balkans that besides affected Austria. An extensive wild animal vaccination campaign eliminated the virus from Italy again, and information technology regained the rabies-costless country status in 2013, the concluding reported example of rabies beingness reported in a red fob in early on 2011.[104] [105]

The United kingdom has been gratis of rabies since the early 20th century except for a rabies-like virus in a few Daubenton's bats. In that location has been one fatal instance of transmission to a human being. There take been iv deaths from rabies, transmitted abroad by domestic dog bites, since 2000. The last infection in the UK occurred in 1922, and the terminal expiry from ethnic rabies was in 1902.[106] [107] Dissimilar many of the other countries of Europe it is protected by being an island, and past strict quarantine procedures.[ commendation needed ]

United mexican states

Mexico was certified by the World Health System as being free of canis familiaris-transmitted rabies in 2019 because no case of dog-human transmission had been recorded in two years.[108]

History

Rabies has been known since around 2000 BC.[109] The first written record of rabies is in the Mesopotamian Codex of Eshnunna (circa 1930 BC), which dictates that the owner of a domestic dog showing symptoms of rabies should take preventive measures against bites. If another person were bitten by a rabid dog and later died, the owner was heavily fined.[110]

In Aboriginal Greece, rabies was supposed to be caused by Lyssa, the spirit of mad rage.[111]

Ineffective folk remedies abounded in the medical literature of the ancient earth. The dr. Scribonius Largus prescribed a poultice of cloth and hyena pare; Antaeus recommended a grooming made from the skull of a hanged man.[112]

Rabies appears to accept originated in the Old Earth, the first epizootic in the New World occurring in Boston in 1768.[113] It spread from in that location, over the adjacent few years, to various other states, likewise as to the French Westward Indies, eventually becoming common all across Due north America.[ citation needed ]

Rabies was considered a scourge for its prevalence in the 19th century. In French republic and Kingdom of belgium, where Saint Hubert was venerated, the "St Hubert's Key" was heated and applied to cauterize the wound. Past an application of magical thinking, dogs were branded with the key in hopes of protecting them from rabies.

It was not uncommon for a person bitten by a domestic dog merely suspected of being rabid to commit suicide or to be killed by others.[20]

In ancient times the attachment of the tongue (the lingual frenulum, a mucous membrane) was cut and removed as this was where rabies was idea to originate. This practice ceased with the discovery of the actual cause of rabies.[31] Louis Pasteur's 1885 nerve tissue vaccine was successful, and was progressively improved to reduce oftentimes severe side-effects.[21]

In modern times, the fear of rabies has not diminished, and the disease and its symptoms, particularly agitation, have served as an inspiration for several works of zombie or similarly themed fiction, often portraying rabies as having mutated into a stronger virus which fills humans with murderous rage or incurable illness, bringing nigh a devastating, widespread pandemic.[114]

Other animals

Rabies is infectious to mammals; three stages of central nervous arrangement infection are recognized. The kickoff stage is a one- to three-twenty-four hour period menstruation characterized past behavioral changes and is known as the prodromal stage. The 2nd is the excitative phase, which lasts three to four days. This stage is often known as "furious rabies" for the tendency of the affected animal to be hyper-reactive to external stimuli and seize with teeth at anything about. The third is the paralytic stage and is caused past damage to motor neurons. Incoordination is seen, owing to rear limb paralysis, and drooling and difficulty swallowing is caused by paralysis of facial and throat muscles. Expiry is usually caused by respiratory arrest.[116]

Research

The outer beat out of the rabies virus, stripped of its RNA contents and thus unable to cause illness, may exist used as a vector for the delivery of unrelated genetic material in a enquiry setting. Information technology has the advantage over other pseudotyping methods for gene delivery in that the cell targeting (tissue tropism) is more than specific for the central nervous arrangement, a difficult-to-reach site, obviating the need for invasive commitment methods. It is as well capable of infecting neighboring "upstream" cells, moving from one cell to axons of the next at synapses, and is thus used for retrograde tracing in neuronal circuits.[117]

Evidence indicates artificially increasing the permeability of the claret–brain bulwark, which normally does non permit nearly immune cells beyond, promotes viral clearance.[118] [119]

See also

  • Global Alliance for Rabies Control
  • Rabies in Haiti
  • Eradication of infectious diseases

References

  1. ^ a b c d due east f yard h i j k 50 k north o p q r s t u "Rabies Fact Sheet N°99". World Health Organization. July 2013. Archived from the original on 1 April 2014. Retrieved 28 February 2014.
  2. ^ "Rabies - Symptoms and causes". Mayo Clinic . Retrieved 9 Apr 2018.
  3. ^ Clinic, mayo clinic. "Rabies". mayoclinic.org. Mayo Dispensary. Retrieved 9 June 2022.
  4. ^ a b c "Rabies, Australian bat lyssavirus and other lyssaviruses". The Section of Health. December 2013. Archived from the original on 4 March 2014. Retrieved 1 March 2014.
  5. ^ a b "Rabies". CDC. 29 July 2020. Retrieved 31 January 2021.
  6. ^ "Rabies, Symptoms, Causes, Treatment". Medical News Today. 15 Nov 2017.
  7. ^ "Rabies, Symptoms and causes". Mayo Clinic.
  8. ^ "Animal bites and rabies". Johns Hopkins Medicine. 27 Feb 2020.
  9. ^ a b c d Cotran RS, Kumar V, Fausto Northward (2005). Robbins and Cotran Pathologic Ground of Illness (7th ed.). Elsevier/Saunders. p. 1375. ISBN978-0-7216-0187-eight.
  10. ^ a b c Tintinalli JE (2010). Emergency Medicine: A Comprehensive Written report Guide (Emergency Medicine (Tintinalli)). McGraw-Loma. pp. Chapter 152. ISBN978-0-07-148480-0.
  11. ^ Wunner WH (2010). Rabies: Scientific Footing of the Disease and Its Direction. Academic Printing. p. 556. ISBN9780080550091.
  12. ^ Manoj Southward, Mukherjee A, Johri Southward, Kumar KV (2016). "Recovery from rabies, a universally fatal disease". Military Medical Research. iii (one): 21. doi:10.1186/s40779-016-0089-y. PMC4947331. PMID 27429788.
  13. ^ Weyer, Jacqueline; Msimang-Dermaux, Veerle; Paweska, Janusz T; le Roux, Kevin; Govender, Premi; Coertse, Jessica; Markotter, Wanda; Nel, Louis H; Blumberg, Lucille H (nine June 2016). "A instance of human survival of rabies, South Africa". Southern African Journal of Infectious Diseases. 31 (2): 66–68. doi:ten.1080/23120053.2016.1128151. ISSN 2312-0053.
  14. ^ "Rabies: The Facts" (PDF). World Health System. Archived (PDF) from the original on 24 Feb 2017. Retrieved 24 February 2017.
  15. ^ WHO Good Consultation on Rabies : second written report (PDF) (2 ed.). Geneva: WHO. 2013. p. 3. ISBN9789241209823. Archived (PDF) from the original on 20 Oct 2014.
  16. ^ a b "Rabies-Gratuitous Countries and Political Units". CDC. Archived from the original on 5 March 2014. Retrieved eight May 2019.
  17. ^ "Neglected Tropical Diseases". cdc.gov. 6 June 2011. Archived from the original on 4 December 2014. Retrieved 28 November 2014.
  18. ^ Simpson DP (1979). Cassell's Latin Dictionary (5 ed.). London: Cassell. p. 883. ISBN978-0-304-52257-6.
  19. ^ Dalfardi B, Esnaashary MH, Yarmohammadi H (February 2014). "Rabies in medieval Persian literature - the Canon of Avicenna (980-1037 AD)". Infectious Diseases of Poverty. 3 (1): 7. doi:10.1186/2049-9957-three-7. PMC3933285. PMID 24533686.
  20. ^ a b Rotivel Y. "Introduction". Federation of American Scientists. Archived from the original on 26 April 2009. Retrieved 25 April 2009.
  21. ^ a b c d due east f thou Giesen A, Gniel D, Malerczyk C (March 2015). "30 Years of rabies vaccination with Rabipur: a summary of clinical data and global experience". Expert Review of Vaccines (Review). 14 (3): 351–67. doi:10.1586/14760584.2015.1011134. PMID 25683583.
  22. ^ Rupprecht CE, Willoughby R, Slate D (Dec 2006). "Current and future trends in the prevention, treatment and command of rabies". Expert Review of Anti-Infective Therapy. 4 (vi): 1021–38. doi:x.1586/14787210.four.6.1021. PMID 17181418. S2CID 36979186.
  23. ^ Cliff Advertising, Haggett P, Smallman-Raynor One thousand (2004). World atlas of epidemic diseases. London: Arnold. p. 51. ISBN9780340761717.
  24. ^ a b "Symptoms of rabies". NHS.uk. 12 June 2012. Archived from the original on fourteen September 2014. Retrieved three September 2014.
  25. ^ "Rabies". AnimalsWeCare.com. Archived from the original on 3 September 2014.
  26. ^ van Thiel PP, de Bie RM, Eftimov F, Tepaske R, Zaaijer HL, van Doornum GJ, et al. (July 2009). "Fatal human rabies due to Duvenhage virus from a bat in Kenya: failure of treatment with blackout-induction, ketamine, and antiviral drugs". PLOS Neglected Tropical Diseases. iii (vii): e428. doi:10.1371/journal.pntd.0000428. PMC2710506. PMID 19636367.
  27. ^ a b c Drew WL (2004). "Chapter 41: Rabies". In Ryan KJ, Ray CG (eds.). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 597–600. ISBN978-0-8385-8529-0.
  28. ^ Finke Due south, Conzelmann KK (August 2005). "Replication strategies of rabies virus". Virus Enquiry. 111 (2): 120–31. doi:10.1016/j.virusres.2005.04.004. PMID 15885837.
  29. ^ a b c d e "Rabies Mail service-Exposure Prophylaxis". Centers for Disease Control and Prevention (CDC). 23 December 2009. Archived from the original on 1 February 2010. Retrieved 30 January 2010.
  30. ^ Gluska S, Zahavi EE, Chein M, Gradus T, Bauer A, Finke Southward, Perlson East (August 2014). "Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal send mechanism". PLOS Pathogens. 10 (8): e1004348. doi:10.1371/journal.ppat.1004348. PMC4148448. PMID 25165859.
  31. ^ a b Baer G (1991). The Natural History of Rabies. CRC Press. ISBN9780849367601 . Retrieved 31 Oct 2011.
  32. ^ Shannon LM, Poulton JL, Emmons RW, Woodie JD, Fowler ME (Apr 1988). "Serological survey for rabies antibodies in raptors from California". Journal of Wild animals Diseases. 24 (2): 264–seven. doi:10.7589/0090-3558-24.2.264. PMID 3286906.
  33. ^ Gough PM, Jorgenson RD (July 1976). "Rabies antibodies in sera of wild birds". Journal of Wildlife Diseases. 12 (3): 392–5. doi:10.7589/0090-3558-12.iii.392. PMID 16498885.
  34. ^ Jorgenson RD, Gough PM, Graham DL (July 1976). "Experimental rabies in a great horned owl". Journal of Wildlife Diseases. 12 (3): 444–7. doi:10.7589/0090-3558-12.3.444. PMID 16498892. S2CID 11374356.
  35. ^ Wong D. "Rabies". Wong's Virology. Archived from the original on 3 December 2008. Retrieved 19 March 2009.
  36. ^ Campbell JB, Charlton K (1988). Developments in Veterinary Virology: Rabies. Springer. p. 48. ISBN978-0-89838-390-4.
  37. ^ "Rabies". World Health Organization. 21 Apr 2020. Retrieved 3 May 2021.
  38. ^ Pawan JL (1959). "The manual of paralytic rabies in Trinidad by the vampire bat (Desmodus rotundus murinus Wagner". Caribbean Medical Journal. 21: 110–36. PMID 13858519.
  39. ^ Pawan JL (1959). "Rabies in the vampire bat of Trinidad, with special reference to the clinical form and the latency of infection". Caribbean Medical Journal. 21: 137–56. PMID 14431118.
  40. ^ Taylor PJ (December 1993). "A systematic and population genetic approach to the rabies problem in the xanthous mongoose (Cynictis penicillata)". The Onderstepoort Periodical of Veterinary Research. 60 (4): 379–87. PMID 7777324.
  41. ^ "Rabies. Other Wild Animals: Terrestrial carnivores: raccoons, skunks and foxes". Centers for Illness Command and Prevention(CDC). Archived from the original on twenty December 2010. Retrieved 23 December 2010.
  42. ^ Anderson J, Frey R (2006). "Rabies". In Fundukian LJ (ed.). Gale Encyclopedia of Medicine (third ed.).
  43. ^ McRuer DL, Jones KD (May 2009). "Behavioral and nutritional aspects of the Virginian opossum (Didelphis virginiana)". The Veterinary Clinics of N America. Exotic Animal Practice. 12 (2): 217–36, viii. doi:10.1016/j.cvex.2009.01.007. PMID 19341950.
  44. ^ Gaughan, John B.; Hogan, Lindsay A.; Wallage, Andrea (2015). Abstract: Thermoregulation in marsupials and monotremes, chapter of Marsupials and monotremes: nature'southward enigmatic mammals. ISBN9781634834872 . Retrieved 20 April 2022.
  45. ^ The Merck Transmission (11th ed.). 1983. p. 183.
  46. ^ The Merck manual of Medical Information (Second Home ed.). 2003. p. 484.
  47. ^ Turton J (2000). "Rabies: a killer disease". National Department of Agriculture. Archived from the original on 23 September 2006.
  48. ^ Jackson AC, Wunner WH (2002). Rabies. Academic Press. p. 290. ISBN978-0-12-379077-4. Archived from the original on viii January 2014.
  49. ^ Lynn DJ, Newton HB, Rae-Grant AD (2012). The 5-Minute Neurology Consult. Lippincott Williams & Wilkins. pp. 414–. ISBN978-1-4511-0012-9.
  50. ^ Davis LE, King MK, Schultz JL (fifteen June 2005). Fundamentals of neurologic disease. Demos Medical Publishing. p. 73. ISBN978-1-888799-84-2. Archived from the original on viii January 2014.
  51. ^ RabiesAlliance.org Archived 24 September 2016 at the Wayback Machine
  52. ^ Srinivasan A, Burton EC, Kuehnert MJ, Rupprecht C, Sutker WL, Ksiazek TG, et al. (March 2005). "Transmission of rabies virus from an organ donor to four transplant recipients". The New England Journal of Medicine. 352 (11): 1103–eleven. doi:x.1056/NEJMoa043018. PMID 15784663.
  53. ^ "Human being Rabies Prevention --- The states, 2008 Recommendations of the Advisory Committee on Immunization Practices". Centers for Illness Control and Prevention. 23 May 2008. Retrieved 11 February 2020.
  54. ^ Kahn CM, Line South, eds. (2010). The Merck Veterinarian Manual (tenth ed.). Kendallville, Indiana: Courier Kendallville, Inc. p. 1193. ISBN978-0-911910-93-iii.
  55. ^ Dean DJ, Abelseth MK (1973). "Ch. 6: The fluorescent antibody test". In Kaplan MM, Koprowski H (eds.). Laboratory techniques in rabies. Monograph serial. Vol. 23 (tertiary ed.). World Health Arrangement. p. 73. ISBN9789241400237.
  56. ^ a b Fooks AR, Johnson Northward, Freuling CM, Wakeley PR, Banyard Ac, McElhinney LM, et al. (September 2009). "Emerging technologies for the detection of rabies virus: challenges and hopes in the 21st century". PLOS Neglected Tropical Diseases. 3 (9): e530. doi:10.1371/journal.pntd.0000530. PMC2745658. PMID 19787037.
  57. ^ Tordo Northward, Bourhy H, Sacramento D (1994). "Ch. x: PCR engineering science for lyssavirus diagnosis". In Clewley JP (ed.). The Polymerase Concatenation Reaction (PCR) for Human being Viral Diagnosis. CRC Press. pp. 125–145. ISBN978-0-8493-4833-4.
  58. ^ David D, Yakobson B, Rotenberg D, Dveres Due north, Davidson I, Stram Y (June 2002). "Rabies virus detection by RT-PCR in decomposed naturally infected brains". Veterinary Microbiology. 87 (2): 111–8. doi:10.1016/s0378-1135(02)00041-x. PMID 12034539.
  59. ^ Biswal M, Ratho R, Mishra B (September 2007). "Usefulness of reverse transcriptase-polymerase chain reaction for detection of rabies RNA in archival samples". Japanese Journal of Infectious Diseases. 60 (5): 298–9. PMID 17881871.
  60. ^ a b c d Ly Southward, Buchy P, Heng NY, Ong S, Chhor N, Bourhy H, Vong South (September 2009). Carabin H (ed.). "Rabies state of affairs in Cambodia". PLOS Neglected Tropical Diseases. 3 (9): e511. doi:10.1371/journal.pntd.0000511. PMC2731168. PMID 19907631. e511.
  61. ^ Dürr Due south, Naïssengar S, Mindekem R, Diguimbye C, Niezgoda Grand, Kuzmin I, et al. (March 2008). Cleaveland Southward (ed.). "Rabies diagnosis for developing countries". PLOS Neglected Tropical Diseases. ii (3): e206. doi:10.1371/journal.pntd.0000206. PMC2268742. PMID 18365035. e206.
  62. ^ a b "New Rapid Rabies Examination Could Revolutionize Testing and Treatment | CDC Online Newsroom | CDC". www.cdc.gov. 16 May 2018. Retrieved 23 May 2018.
  63. ^ "Rabies: Differential Diagnoses & Workup". eMedicine Infectious Diseases. 3 Oct 2008. Archived from the original on 28 Nov 2010. Retrieved xxx Jan 2010.
  64. ^ Taylor DH, Straw Exist, Zimmerman JL, D'Allaire S (2006). Diseases of swine. Oxford: Blackwell. pp. 463–v. ISBN978-0-8138-1703-3 . Retrieved 30 January 2010.
  65. ^ Minagar A, Alexander JS (2005). Inflammatory Disorders Of The Nervous System: Pathogenesis, Immunology, and Clinical Direction. Humana Printing. ISBN978-i-58829-424-1.
  66. ^ Geison GL (April 1978). "Pasteur's work on rabies: reexamining the upstanding issues". The Hastings Center Study. 8 (ii): 26–33. doi:10.2307/3560403. JSTOR 3560403. PMID 348641.
  67. ^ Srivastava AK, Sardana V, Prasad K, Behari 1000 (March 2004). "Diagnostic dilemma in flaccid paralysis following anti-rabies vaccine". Neurology Bharat. 52 (ane): 132–iii. PMID 15069272. Archived from the original on ii Baronial 2009.
  68. ^ Reece JF, Chawla SK (September 2006). "Control of rabies in Jaipur, India, by the sterilisation and vaccination of neighbourhood dogs". The Veterinarian Record. 159 (12): 379–83. doi:10.1136/vr.159.12.379. PMID 16980523. S2CID 5959305.
  69. ^ "Compendium of Animal Rabies Prevention and Control" (PDF). National Clan of Country Public Health Veterinarians. 31 December 2007. Archived from the original (PDF) on 12 July 2010. Retrieved three Jan 2010.
  70. ^ 2007 Almanac Report (PDF) (Report). Bureau of Catching Illness Control and Prevention. 2007.
  71. ^ "Earth Rabies Day". World Health Organisation (WHO). Archived from the original on 31 December 2011.
  72. ^ Meltzer MI (October–Dec 1996). "Assessing the costs and benefits of an oral vaccine for raccoon rabies: a possible model". Emerging Infectious Diseases. 2 (4): 343–nine. doi:ten.3201/eid0204.960411. PMC2639934. PMID 8969251.
  73. ^ a b c Grambo RL (1995). The Globe of the Fox . Vancouver: Greystone Books. pp. 94–5. ISBN978-0-87156-377-four.
  74. ^ "Rabies in the U.S." Centers for Illness Control and Prevention (CDC). 22 Apr 2011. Archived from the original on 31 December 2011. Retrieved 31 December 2011.
  75. ^ a b Lite J (8 Oct 2008). "Medical Mystery: Only One Person Has Survived Rabies without Vaccine—Merely How?". Scientific American. Archived from the original on five November 2009. Retrieved thirty January 2010.
  76. ^ "Homo rabies: ameliorate coordination and emerging engineering science to improve access to vaccines". Globe Health Organization. Archived from the original on 24 Feb 2017. Retrieved 23 February 2017.
  77. ^ "Use of a Reduced (4-Dose) Vaccine Schedule for Postexposure Prophylaxis to Prevent Human Rabies" Archived 25 July 2011 at the Wayback Automobile. Centers for Disease Control and Prevention (CDC).
  78. ^ "Toll of Rabies Prevention". 11 June 2019. Archived from the original on 29 March 2016.
  79. ^ "BNF is only bachelor in the UK".
  80. ^ "Milton Keynes Formulary Formulary".
  81. ^ "Rabies - Vaccination". 23 October 2017.
  82. ^ Park'southward Textbook of Community Medicine, 22nd edition, 2013, p 254.
  83. ^ "Rabies". World Wellness Organization. Archived from the original on xv Feb 2015. Retrieved ane February 2015.
  84. ^ "Rabies & Australian bat lyssavirus data canvas". Health.vic.gov.au. Archived from the original on 18 August 2011. Retrieved thirty January 2012.
  85. ^ National Center for Disease Command (2014). "National Guidelines on Rabies Prophylaxis" (PDF). Archived from the original (PDF) on 5 September 2014. Retrieved 5 September 2014.
  86. ^ De Serres G, Skowronski DM, Mimault P, Ouakki M, Maranda-Aubut R, Duval B (June 2009). "Bats in the bedroom, bats in the belfry: reanalysis of the rationale for rabies postexposure prophylaxis". Clinical Infectious Diseases. 48 (11): 1493–1499. doi:ten.1086/598998. PMID 19400689.
  87. ^ Despond O, Tucci Yard, Decaluwe H, Grégoire MC, Southward Teitelbaum J, Turgeon North (March 2002). "Rabies in a nine-year-former kid: The myth of the bite". The Canadian Journal of Infectious Diseases. 13 (ii): 121–125. doi:10.1155/2002/475909. PMC2094861. PMID 18159381.
  88. ^ "Milwaukee Protocol, version half dozen (updated November 2018)" (PDF).
  89. ^ Ledesma, 50. A.; Lemos, Eastward. R.; Horta, M. A. (2020). "Comparison clinical protocols for the treatment of man rabies: the Milwaukee protocol and the Brazilian protocol (Recife)". Revista da Sociedade Brasileira de Medicina Tropical. 53: e20200352. doi:10.1590/0037-8682-0352-2020. PMC7670764. PMID 33174958.
  90. ^ a b "Rabies". World Wellness Organization (WHO). September 2011. Archived from the original on 31 December 2011. Retrieved 31 December 2011.
  91. ^ Lozano R, Naghavi M, Foreman K, Lim South, Shibuya M, Aboyans V, et al. (December 2012). "Global and regional mortality from 235 causes of decease for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2095–128. doi:10.1016/S0140-6736(12)61728-0. hdl:10536/DRO/DU:30050819. PMID 23245604. S2CID 1541253.
  92. ^ Hampson Yard, Coudeville 50, Lembo T, Sambo M, Kieffer A, Attlan M, et al. (April 2015). "Estimating the global brunt of owned canine rabies". PLOS Neglected Tropical Diseases. 9 (4): e0003709. doi:10.1371/journal.pntd.0003709. PMC4400070. PMID 25881058.
  93. ^ "Rabies". World Health System. Archived from the original on 15 Feb 2017. Retrieved 23 Feb 2017.
  94. ^ Dugan E (thirty April 2008). "Dead as a dodo? Why scientists fear for the futurity of the Asian vulture". The Independent. London. Archived from the original on 17 May 2008. Retrieved 11 October 2008. India now has the highest rate of man rabies in the world.
  95. ^ a b Harris G (6 August 2012). "Where Streets Are Thronged With Strays Baring Fangs". New York Times. Archived from the original on 8 Baronial 2012. Retrieved half-dozen August 2012.
  96. ^ Medicine challenges Indian superstition | Asia | DW.DE | 31.12.2012 Archived 31 January 2013 at the Wayback Machine
  97. ^ "Essential rabies maps" Archived 17 February 2010 at the Wayback Automobile. Earth Health Organization (WHO).
  98. ^ "CDC – Rabies Surveillance in the U.South.: Human being Rabies – Rabies". www.cdc.gov. Archived from the original on 18 January 2017. Retrieved 10 April 2017.
  99. ^ Fox 1000 (7 September 2007). "U.South. gratis of canine rabies virus". Reuters. Archived from the original on 17 May 2017. Retrieved 11 April 2017. "We don't desire to misconstrue that rabies has been eliminated – dog rabies virus has been," CDC rabies expert Dr. Charles Rupprecht told Reuters in a telephone interview.
  100. ^ a b Pieracci EG, Pearson CM, Wallace RM, Blanton JD, Whitehouse ER, Ma X, et al. (June 2019). "Vital Signs: Trends in Human Rabies Deaths and Exposures - Usa, 1938-2018". MMWR. Morbidity and Mortality Weekly Report. 68 (23): 524–528. doi:ten.15585/mmwr.mm6823e1. PMC6613553. PMID 31194721.
  101. ^ "A Man Died From Rabies In Illinois. Here'south Why That's And then Unusual In The U.Due south." NPR. 29 September 2021.
  102. ^ "SURVEILLANCE REPORT - Annual Epidemiological Report for 2015 - Rabies, ECDC (European Centre for Disease Prevention and Control)" (PDF) . Retrieved thirty August 2018.
  103. ^ "Switzerland concluded rabies epidemic by air dropping vaccinated chicken heads from helicopters / thefactsource.com". 20 November 2019. Retrieved ten December 2019.
  104. ^ "Rabies in Africa: The RESOLAB network". 29 June 2015. Archived from the original on iii Baronial 2016. Retrieved xviii April 2016.
  105. ^ "Ministero della Salute: "Italia è indenne dalla rabbia". l'Ultimo caso nel 2011 - Quotidiano Sanità". Archived from the original on iii June 2016. Retrieved xviii April 2016.
  106. ^ "Rabies". NHS. 23 February 2017. Retrieved xxx August 2018.
  107. ^ "Q&A: Rabies". BBC News. 17 April 2015. Retrieved thirty August 2018.
  108. ^ "Cómo México se convirtió en el primer país del mundo libre de rabia transmitida por perros". BBC News. 12 November 2019. Retrieved 12 November 2019.
  109. ^ Adamson PB (1977). "The spread of rabies into Europe and the probable origin of this illness in antiquity". Journal of the Royal Asiatic Society of Great United kingdom & Ireland. Majestic Asiatic Social club of Great Britain and Ireland. 109 (two): 140–4. doi:10.1017/S0035869X00133829. JSTOR 25210880. PMID 11632333.
  110. ^ Dunlop RH, Williams DJ (1996). Veterinary Medicine: An Illustrated History. Mosby. ISBN978-0-8016-3209-nine.
  111. ^ "Rabies: an ancient disease".
  112. ^ Barrett AD, Stanberry LR (2009). Vaccines for Biodefense and Emerging and Neglected Diseases. Academic Press. p. 612. ISBN9780080919027. Archived from the original on 28 Apr 2016. Retrieved 8 January 2016.
  113. ^ The Natural History of Rabies Archived 2 March 2016 at the Wayback Machine
    The beginning major epizootic in North America was reported in 1768, continuing until 1771 when foxes and dogs carried the affliction to swine and domestic animals. The malady was and then unusual that it was reported equally a new disease
  114. ^ Than Thou (27 October 2010). "'Zombie Virus' Possible via Rabies-Flu Hybrid?". National Geographic. Archived from the original on 13 September 2015. Retrieved 13 September 2015.
  115. ^ Santo Tomás Pérez, Magdalena (2002). La asistencia a los enfermos en Castilla en la Baja Edad Media. Universidad de Valladolid. pp. 172–173. ISBN84-688-3906-X – via Biblioteca Virtual Miguel de Cervantes.
  116. ^ Ettinger SJ, Feldman EC (1995). Textbook of Veterinary Internal Medicine (4th ed.). W.B. Saunders Visitor. ISBN978-0-7216-6795-9.
  117. ^ Carpentier DC, Vevis K, Trabalza A, Georgiadis C, Ellison SM, Asfahani RI, Mazarakis ND (July 2012). "Enhanced pseudotyping efficiency of HIV-ane lentiviral vectors by a rabies/vesicular stomatitis virus chimeric envelope glycoprotein". Gene Therapy. 19 (seven): 761–74. doi:ten.1038/gt.2011.124. PMID 21900965.
  118. ^ Roy A, Hooper DC (August 2007). "Lethal silvery-haired bat rabies virus infection tin can be prevented by opening the blood-brain bulwark". Journal of Virology. 81 (15): 7993–viii. doi:10.1128/JVI.00710-07. PMC1951307. PMID 17507463.
  119. ^ Roy A, Phares TW, Koprowski H, Hooper DC (February 2007). "Failure to open up the blood-brain barrier and deliver immune effectors to primal nervous system tissues leads to the lethal outcome of silvery-haired bat rabies virus infection". Periodical of Virology. 81 (3): 1110–eight. doi:10.1128/JVI.01964-06. PMC1797506. PMID 17108029.

External links

  • Rabies at Curlie
  • "Rabies". Centers for Disease Command and Prevention. Retrieved 12 August 2012.
  • Virus Pathogen Database and Assay Resource (ViPR): Rhabdoviridae
  • OIE'southward Rabies Portal Archived 13 August 2020 at the Wayback Machine
  • Aerophobia and Hydrophobia in Rabies Videos
  • "Rabies virus". NCBI Taxonomy Browser. 11292.

Source: https://en.wikipedia.org/wiki/Rabies

Posted by: eddythavess.blogspot.com

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